In a similar study, using the same chondrosarcoma cell line, Kobayashi et al., demonstrated that the mRNA and protein of the urokinase-type plasminogen activator (uPA) and theurokinase-type plasminogen activator receptor (uPAR) were upregulated after CD44 stimulation with LMW-HA. The gene discussed is PLAU; the disease is chondrosarcoma.