Concordantly, a similar study performed by Gvozdenovic et al., in 143B osteosarcoma cell line using an shRNA-silencing approach to downregulate CD44 expression, resulted in a decrease in the adhesion of osteosarcoma cells to HA, migration, and a diminished capacity to growth anchorage independent in soft agar. The gene discussed is CD44; the disease is osteosarcoma.