Supporting the role of the CD44v6 marker in osteosarcoma, two meta-analyses (both with more than 460 osteosarcoma cases) focused on the prognostic utility of this specific CD44 isoform revealed that its overexpression is associated with the overall survival rate and the occurrence of metastatic events and could be used as a complementary diagnostic marker in osteosarcoma (176, 177). The gene discussed is CD44; the disease is osteosarcoma.