AKT1 and neoplasm: These interactions trigger changes in the tumor cell cytoskeletal architecture and cell signaling (e.g., c-Met activation, Ras-MAPK cascade, Snail/β-catenin translocation, or PI3K-AKT pathway activation), playing a role in the regulation of epithelial‐mesenchymal transition mechanisms (EMT) and the activation of angiogenesis, proliferation, and invasion mechanisms (70, 71).