In the TCGA-LUAD dataset, we found that DCPS, EIF4E1B, EIF4G3, LARP1, LSM1, METTL1, NCBP1, NCBP2, NSUN2, and WDR4 were significantly upregulated in tumor tissues than in adjacent normal tissues (|log2FC| > 0.585, p < 0.05), which were further validated in protein levels using the IHC results from the HPA platform; moreover, high expressions of DCPS, EIF4G3, LARP1, METTL1, NCBP1, NCBP2, and WDR4 predicted a significantly poor OS. This evidence concerns the gene NSUN2 and neoplasm.