(43), EIF4G3, encoding a eukaryotic translation initiation factor involved in mRNA cap recognition and transport of mRNAs to the ribosome, was found to be a direct target of miR-375 in lung squamous cell carcinoma cells, and silencing of EIF4G3 induced cell apoptosis and suppressed tumor growth. The gene discussed is EIF4G3; the disease is neoplasm.