A prognostic gene model based on eight prognostic PRGs (CASP4, GSDMC, IL-18, NLRP1, NLRP2, PLCG1, TIRAP, and TNF) was constructed using LASSO Cox regression analysis and could predict the overall survival of PC patients with medium-to-high accuracy. Here, CASP4 is linked to pachyonychia congenita.