Discovered some GC lymph node metastasis marker genes (ERBB2, CLDN11 and CDK12), as well as potential gastric cancer evolution−driving genes (FOS and JUN).ERBB4, NOTCH2, KIF5B and NOTCH2NL were highly expressed in primary cancer, while CDK12, CLDN11 and ERBB2 were over expressed in metastatic cancer. Here, NOTCH2 is linked to metastatic malignant neoplasm.