Furthermore, by transplanting two GC cell lines into mice and performing single-cell transcriptome sequencing of the transplanted tumors, Nagaoka confirmed that interleukin-17 (IL-17) could be a potential target for enhanced programmed cell death 1, anti-PD-1 (programmed cell death protein 1) mAb treatment for GC (31). Here, PDCD1 is linked to gastric cancer.