The CRC-specific T cell subpopulation, included Th17 (CD4_C08-IL23R), follicular T helper cells (CD4_C06-CXCR5), follicular T regulatory cells (CD4_C11-IL10), CD8_C05-CD6, and CD8_C06-CD160. The latter two clusters highly expressed CD69 and ITGAE. This evidence concerns the gene CD6 and colorectal carcinoma.