Another study examined TAMs in CRC and found that Bcl9 deficiency caused macrophage polarization inhibition from M0 to M2 and altered the CRC tumor microenvironment to further interfere with the inflammation of M0 and M1, the cell type balance and transcription differences in TAMs regulated by BCL9-driven Wnt signaling affected immune surveillance and inflammation in cancer (55). The gene discussed is BCL9; the disease is neoplasm.