performed SCS to classify PC samples into two subtypes that were predicted independent of clinical variables, obtained and verified the prognostic markers of 12 genes (TPM2, FCGBP, CDK6, NCBP2, CLCX3, PIGR, BTF3, CKB, VPS28, TM4SF1, EIF3E, GPX4) in multiple large-scale gastric adenocarcinoma (GAC) cohorts (16). The gene discussed is GPX4; the disease is gastric adenocarcinoma.