CLDN11 and cancer: Discovered some GC lymph node metastasis marker genes (ERBB2, CLDN11 and CDK12), as well as potential gastric cancer evolution−driving genes (FOS and JUN).ERBB4, NOTCH2, KIF5B and NOTCH2NL were highly expressed in primary cancer, while CDK12, CLDN11 and ERBB2 were over expressed in metastatic cancer.