These new driver mutations in OR1B1 (GPCR signaling), LAMA1 (PI3K-Akt signal in CRC evolution), and ADCY3 (FGFR signaling) of adenoma evolution and cancer evolution, confirming that both colorectal adenomas and CRC were of monoclonal origin (47). The gene discussed is AKT1; the disease is colorectal carcinoma.