BRCA2 and cancer: According to the cancer genome atlas (TCGA), high grade serous ovarian cancers (HGSOCs) are characterized by frequent genetic and epigenetic alterations of HR pathway genes, most commonly BRCA1 and BRCA2. In addition, approximately 50% of patients with HGSOC exhibit genetic and epigenetic alterations in the FANC-BRCA (Figure 1) pathway (11).