There are also two studies that report a correlation of serum TN-C with prognostic factors of cancers: In non-small cell lung cancer patients TN-C serum levels correlated with larger tumor size, lymph node metastases and patient’s overall survival (51), while serum TN-C levels in grade 3 breast cancer were significantly higher than in grade 1-2 tumors (50). This evidence concerns the gene TNC and neoplasm.