For TN-C, it is known that its presence in the mesenchyme results in increased levels of the pro-angiogenic factor VEGF in A375 melanoma cell transplant experiments (120) and TN-C is able to repress Wnt signaling by DKK1 in tumor and endothelial cells creating a proangiogenic TME (121). Here, DKK1 is linked to neoplasm.