While an anti-proliferative activity was reported for TN-W in the murine osteoblastic cells MC3T3 (92), treatment of MDA-MB231-1833 breast cancer cells with different concentrations of recombinant TN-W resulted in a significant increase of BrdU incorporation, suggesting that TN-W is able to stimulate cancer cell proliferation (91). This evidence concerns the gene TNC and breast carcinoma.