Several TN-C-specific aptamers have been developed that can be used as imaging tools [99mTc-TTA1 (170–172) and GBI-10 aptamers (173)] and PET tracers [18F-Fb-TN-C and 64Cu-NOTA-TN-C aptamers (174)] to localize and detect tumor-specific TN-C expression allowing the planning of personalized treatment strategies as well as tumor monitoring. Here, TNC is linked to neoplasm.