STAT3 and neoplasm: The RM9-tumor bearing mice, compared to vehicle-treated animals, also had significant increases in systemic levels of multiple inflammatory cytokines that were either IL-6 family members — IL-6, LIF — or other cytokines such as IL-10 and G-CSF that can also increase JAK/STAT3 signaling in target tissues (Figure 3F) (25–27).