We have ultimately leveraged our novel in vitro adipocyte inflammation assay and its accurate surrogacy of cancer cachexia murine models to prove that IL-6 family cytokines and their induction of JAK/STAT3 signaling are relevant to multiple primary cancer types that induce cachexia-associated adipose wasting, paving the way for the initiation of an early phase clinical trial. The gene discussed is STAT3; the disease is cancer.