PTEN and central nervous system cancer: Besides, mutation of phosphatase and tensin homolog deleted on chromosome ten (PTEN), neurofibromatosis (NF1), isocitrate dehydrogenase (IDH), B-Raf Proto-Oncogene (BRAF), and chromosome 1p19q co-deleted are common in glioma, even being used for molecular classification and prognosis prediction.