HIF1A and periodontal disorder: GO functional enrichment analysis (Figure 2(a)) showed that DEGs were enriched in neutrophil degranulation, neutrophil activation involved in immune response, collagen-containing extracellular matrix, primary lysosome, and vesicle lumen; KEGG pathway analysis (Figure 2(b)) showed that the DEGs were concentrated in the HIF-1 signaling pathway, PI3K-AKT signaling pathway, and cell cycle, whereas DO enrichment analysis (Figure 2(c)) showed that DEGs were significantly expressed in cardiovascular diseases, periodontal disease, and OA.