After adjusting for age, sex, hypertension, and diabetes, logistic regression analysis showed that anti-CCP positivity, AKA positive, and APF positive were all independent risk factors for RA (OR = 20.24, 95% CI: 9.36–43.77, p < 0.01; OR = 4.33, 95% CI: 1.62–11.60, p < 0.01; OR = 5.28, 95% CI: 2.33–11.99, p < 0.01). This evidence concerns the gene NEUROG1 and hypertensive disorder.