This study detected the expression of IL-27 and CXCL9/10/11 in the lesion tissue and peripheral blood of TB patients and preliminarily revealed the relationship between let-7b-5p and miR-30a-3p with IL-27 and CXCL9/10/11; this provides a certain foundation and new ideas for subsequent research. This evidence concerns the gene CXCL9 and tuberculosis.