Then, through bioinformatics methods, further explore the important molecules that are closely related to IL-27, CXCL9, CXCL10, and CXCL11 in the course of tuberculosis, and then, predict miRNA, peripheral blood of tuberculosis patients was collected; the expression of cytokines and miRNA was verified by qPCR. This evidence concerns the gene CXCL11 and tuberculosis.