IRF4 and neoplasm: ART-induced signaling pathway switch in tumor MDSCs leads to inhibit M2-like tumor-promoting gene expression profiles such as Arg1, Il10, Tgfb1, Cd36, Gab1, Bcl2, and Irf4 but triggered M1-like antitumor gene expression patterns like Inos, Tnfa, Il12p40, Cxcr3, Slc1a4, or Slc22a18 (Figures 2(a)–2(c)).