CCL2 and hepatocellular carcinoma: As shown in Figures 3(e)–3(f), CM from HMGA1-siRNA1/2 HCC cells had a reduced chemotactic effect for human monocytes compared with CM from NC-siRNA HCC cells; notably, the addition of recombinant human CCL2 protein in the HMGA1-siRNA1/2 CM increased the migratory ability of human monocytes.