INS and Hypoglycemia: We included studies with several inclusion criteria, including (1) randomized clinical trials, (2) studying a population of T2DM at any age, (3) using IDegAsp as an intervention or independent variable, (4) using another insulin as a controlled variable, (5) analyzing the outcome of IDegAsp use in T2DM, such as HbA1C changes and hypoglycemia events that compared with the control insulin, and (6) written in English.