MMP14 and cancer: It could be explained by the fact that upregulated KIF2A enhanced the capacity of cancer cells to proliferate, invade, and migrate by increasing MT1-MMP or the AKT level (16, 21), as well as repressed their apoptosis by activating the PI3K/Akt signaling pathway (19), leading to its high expression in tumor tissue compared with adjacent tissues in BLBC patients.