The possible mechanisms of Lp-PLA2 inducing HDP are as follows: 1 Lp-PLA2 can combine apolipoprotein B with low density lipoprotein, causing lipid metabolism disorder, and then leading to atherosclerosis of uterine and placental arteries, resulting in decreased placental function, leading to the occurrence of HDP. This evidence concerns the gene PLA2G7 and atherosclerosis.