USP22 and neoplasm: After systematic analysis, it was found that USP22 expression was not correlated with gender (OR = 1.202, 95% CI, 0.877–1.648, P = 0.253) (Figure 3A), age (OR = 1.090, 95% CI, 0.811–1.466, P = 0.568) (Figure 3B), tumor size (OR = 0.693,95% CI, 0.348–1.380, P = 0.297) (Figure 3C), tumor differentiation (OR = 1.830, 95%CI, 0.948–3.531, P = 0.072) (Figure 3D) and depth of invasion (OR = 2.320, 95% CI, 0.684–7.871, P = 0.177) (Figure 3E).