However, the expression of USP22 was correlated with lymph node metastasis (OR = 2.415, 95% CI, 1.082, P = 0.031) (Figure 3F), distant metastasis (OR = 3.956, 95% CI, 1.365–11.464, P = 0.011) (Figure 3G) and TNM stage (OR = 2.973, 95% CI, 1.153–7.666, P = 0.024) (Figure 3H). Here, USP22 is linked to metastatic malignant neoplasm in the lymph nodes.