Figure 2C shows the OEF measurements in the sagittal sinus vein using TRUST (OEF-TRUST). Mean OEF-TRUST measurements were 31.2% in SCD, 33.4% in ACTL and 36.8% in CTL (p < 0.01). After Dunnett’s analysis, we found that SCD was different from CTL (p = 0.0034) and ACTL was not (p = 0.1291). Here, ACAT2 is linked to Schnyder corneal dystrophy.