This reasoning is supported by Du and colleagues who described the role of piR-31115 - also present in our dataset (Supplementary File S2)—in renal cell carcinoma progression by activation of epithelial-mesenchymal transition via the PI3K/AKT signaling, independently of L1 repression (Du et al., 2021), as this piRNA also does not map to LINE-1. The gene discussed is PIR; the disease is hereditary clear cell renal cell carcinoma.