METTL3 and obesity due to melanocortin 4 receptor deficiency: The methyltransferase-like 3 (METTL3)-centered methyltransferase complex catalyzes the addition of the m6A modification, and α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) or fat mass and obesity-associated protein catalyzes the removal from RNA (Punekar et al., 2013; Wang et al., 2016).