MAPT and cervical squamous intraepithelial neoplasia: Abnormal tau is implicated in CIN by both the effects of tau hyper- phosphorylation (as seen in tauopathies) and by mutations of the MAPT gene affecting increased instability and vulnerability of chromatin (Rossi et al., 2013; Alonso et al., 2018; Colnaghi et al., 2020).