Astrocytes are further implicated in many tauopathies including Progressive Supranuclear Palsy, Corticobasal degeneration, and Aging-related tau astrogliopathy, by the presence of tau aggregates in diseased astrocytes (Togo and Dickson, 2002; Kouri et al., 2011; Kovacs et al., 2016; Reid et al., 2020). Here, MAPT is linked to tauopathy.