ALKBH5 exerts tumor-promoting roles in the development and maintenance of AML and self-renewal of leukemia stem/initiating cells (LSCs/LICs) through post-transcriptional regulation of its key target TACC3, AXL (Wang et al., 2020b; Shen et al., 2020). The gene discussed is ALKBH5; the disease is acute myeloid leukemia.