ATG5 and non-small cell lung carcinoma: β-elemene can directly inhibit the expression of METTL3, but not VIRMA and METTL14, causing the down-regulation of autophagy-related proteins LC3B, ATG5, and ATG7, thereby inhibiting autophagy, tumor cell proliferation and promoting cell apoptosis, and finally reversing the effect of gefitinib resistance in NSCLC (Liu et al., 2020).