METTL3 and acute myeloid leukemia: However, the low expression of METTL3 in AML-MSCs (mesenchymal stem cells from AML patients) promotes the expression of AKT protein and upregulate the PI3K-AKT signaling pathway, which ultimately leads to the enhanced adipogenesis ability of AML-MSCs and facilitates the chemoresistance of AML (Pan et al., 2021b).