But there is an interesting study showing that METTL3 has an anti-tumor effect, downregulation of METTL3 decreased protein levels of apoptotic molecules and increased protein levels of the FBXW7 gene and its target genes Mcl-1 and c-Myc, and promotes tumorigenesis in LUAD which may be caused by the heterogeneity of tumor cells (Wu et al., 2021b). Here, FBXW7 is linked to neoplasm.