Several recent studies have reported that chrysin exerts its anti-cancer effects on endometrial cancer, gastric cancer, breast, lung, cervical, bladder, breast cancer, and colorectal cancer, etc. via selectively inhibiting various cell signaling pathways, such as: Akt/mTOR, JNK1/2, ERK1/2, NF-κB, etc., and promoting tumor cells apoptosis and autophagy (Xia et al., 2015a; Xia et al., 2015b; Roy et al., 2019; He et al., 2021). Here, AKT1 is linked to cancer.