β-elemene can directly inhibit the expression of METTL3, but not VIRMA and METTL14, causing the down-regulation of autophagy-related proteins LC3B, ATG5, and ATG7, thereby inhibiting autophagy, tumor cell proliferation and promoting cell apoptosis, and finally reversing the effect of gefitinib resistance in NSCLC (Liu et al., 2020). Here, METTL14 is linked to neoplasm.