In this review, we summarize the biological functions of m6A modification, the role of m6A in tumors, and the related signal pathways of m6A in tumors, such as Akt, NF-kB, MAPK, ERK, and Wnt/β-Catenin, STAT, p53, Notch signaling pathway, etc. Moreover, we also review the research progress of natural products in antitumor, and further understands its antitumor mechanism, so as to provide an implication for the anti-cancer research of natural products via regulating m6A modification in the future. Here, TP53 is linked to cancer.