Most of current drugs treated for VD are Alzheimer’s disease therapeutics such as acetylcholinesterase inhibitors like donepezil, galantamine, and huperzine A, glutamate NMDA receptor antagonists like memantine and calcium antagonists like nimodipine and butalbital (Farooq et al., 2017; Wang, 2020; Song et al., 2021). The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.