Moreover, the angiogenesis inhibition of cryptotanshinone (CPT) was implicated in multi-signaling, including Wnt/β-catenin/VEGF axis, VEGFR2 and its downstream Src/FAK, ERK1/2 in HUVECs, while it leads to the downregulation of PI3K/Akt/mTOR signaling and HIF-1α in CT26 colon cancer cells (Chen et al., 2014; Xu et al., 2017; Zhang et al., 2018b). This evidence concerns the gene VEGFA and colonic neoplasm.