KDR and Familial prostate cancer: The SB lessened tumor angiogenesis in pancreatic cancer and prostate tumor xenograft (Singh et al., 2003; Nambiar et al., 2013), while SB inhibited tumor angiogenesis via restricting VEGF, VEGFR2, HIF-1α, and iNOS expression in a transgenic mouse of prostate cancer (Raina et al., 2008).