In addition, VEGF-A and COX2 mRNA was downregulated by umbelliprenin (UMB, a coumarin from Ferula species) in 4T1 tumor mice (2.5 mg/d), with the protein expression of NF-κB and VCAM1 decreasing (Rashidi et al., 2018). The gene discussed is NFKB1; the disease is neoplasm.