In the study about the cancer-associated glycans and glycosphingolipids of Globo-H ceramide (GHCer), cancer cells derived GHCer through microvesicles were assimilated by HUVECs, leading to the improvement of the angiogenic attribute, of which molecular mechanism involving the interaction between GHCer and TRAX for consequently inducing the activation of PLCβ1, drivers of early angiogenesis (Cheng et al., 2014). Here, PLCB1 is linked to cancer.