The mTOR/p70S6K/4E-BP1 and MAPK signaling pathway involved the anti-angiogenic activity that induced VEGF/HIF-1α suppression of silibinin and imperatorin in cervical and hepatoma cancer cells and colon cancer, respectively (García-Maceira and Mateo, 2009; Mi et al., 2017). The gene discussed is HIF1A; the disease is malignant colon neoplasm.