ELR510444, a small molecule blocking HIF and known as a microtubule blocker, inhibited tumor angiogenesis in mice model of renal cell carcinoma, which was contributed to the suppression of HIF-1α and HIF-1β activity (0-100 nM) and the induction of microtubule destabilization (EC50, 27 nM) (Carew et al., 2012). Here, HIF1A is linked to neoplasm.