KDR and melanoma: The antiangiogeneic effect of Dioscin, a steroid saponin mainly appearing in Dioscorea opposita Thunb, involved the downregulation of p-Src/p-STAT3/VEGF/MMP-2,9 in melanoma, and attenuated VEGFR2 and Akt/MAPK signaling axis in colon cancer, while led to the constraint of VEGF/VEGFR pathway in ovarian cancer cells (Tong et al., 2014; Guo and Ding, 2018; Liu et al., 2022).