BJ-1108, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, inhibited tumor angiogenesis and 5-HT-induced ROS generation that depended on the PI3K/Akt/NOX signaling pathway (0.1.1 μM) in HUVECs (Banskota et al., 2016). Here, AKT1 is linked to neoplasm.