AKT1 and melanoma: Xanthomicrol, a flavone extracted from Dracocephalum kotschyi Boiss leaf, showed an antiangiogeneic effect in mice melanoma (B16F10) model (50 mg/kg) through negatively regulating the expression of VEGF, HIF-1α, and p-Akt (Ghazizadeh et al., 2020).