HIF1A and neoplasm: Regardless of at hypoxia or at normoxia, tanshinone I subdued angiogenesis in epithelial cells (HMEC-1) and the secretion of VEGF from tumor cells (MCF-7) by the common mechanism: deduction of p-STAT3 and HIF-1α, and also inhibited VEGF against lung carcino-angiogenesis (Tung et al., 2013; Wang et al., 2015b).