RGD-NPs induced apoptosis and S phase cell cycle arrest in HUVECs (2-8 μM) and inhibited neo-angiogenesis in BC MCF-7-bearing tumor mice (2.5–7.5 mg/kg) by the downregulation of VEGF-VEGFR2 (Fu et al., 2016). The gene discussed is VEGFA; the disease is breast cancer.