WISP-1/CCN4, an extracellular matrix-associated protein, promoted VEGF-A secretion through the integrin αvβ3/FAK/c-Src axis and the EGFR/ERK/HIF1-α signaling pathway that was transactivated subsequently, in oral squamous cell carcinoma (OSCC), and then the VEGF that CCN4 induced mediated the neovascularization of endothelial progenitor cells (EPCs) trigging (Chuang et al., 2015). This evidence concerns the gene CCN4 and oral cavity squamous cell carcinoma.