In addition, neem leaf glycoprotein (NLGP), a natural immune-modulator obtained from the leaves of neem (Azadirachta indica A. juss), balked M2 polarization of TAMs and HIF1α/VEGF signaling with STAT3-dependent manner and induced tumor vessel normalization with CD8+ T cells dependence by downmodulating VEGF and VEGFR2 (Banerjee et al., 2014; Goswami et al., 2014; Saha et al., 2020). This evidence concerns the gene STAT3 and neoplasm.