KDR and Familial prostate cancer: The two pairs of flavonolignan diastereoisomers (silybin A, silybin B, isosilybin A and isosilybin B) isolated from Silybum marianum (L.)exerted similar effectivity against angiogenesis via downregulating Akt/HIF-1 α/VEGF axis in prostate cancer, and simultaneously modulated VEGF-induced signaling, encompassing VEGFR and its downstream Src, Akt, MAPKs, mTOR and so on in HUVECs (Deep et al., 2012).