, suppressed hypoxia-induced angiogenesis via restricting IL-8/HIF-1α/PI3K and MAPK/ERK pathways in endothelial EA.hy 926 cells, and inhibited the expression of VEGF, HIF-1α, and IL-8 under hypoxic conditions in HCC Huh-7 cells (Lin et al., 2021). This evidence concerns the gene CXCL8 and hepatocellular carcinoma.