VEGFA and lung carcinoma: The VEGF/VEGFR2 pathway and MMP-2/-9 and TIMP-2 expression were downregulated by Tan IIA in HUVECs for countering angiogenesis, while Tan IIA could bind the VEGFR2 kinase domain to inhibit the VEGF/VEGFR axis in lung cancer A549 cells (Tsai et al., 2011; Xie et al., 2015; Xing et al., 2015).