VEGFA and neoplasm: As a part of the anti-tumor mechanism of legume lectin proteins, its anti-angiogenesis effect has been reported that Dolichos lablab L. lectin (DLL) protein weakened the expression of pro-angiogenic factors encompassing NF-κB, HIF-1 α, MMP-2 and 9, and VEGF, while the concanavalin A exhibited anti-angiogenic action via targeting IKK-NF-κB-COX-2, SHP-2-MEK-1-ERK, and SHP-2-Ras-ERK cascade (Li et al., 2011; Vigneshwaran et al., 2017).