NFKB1 and neoplasm: Targeting macrophages in TME, anemoside A3 derived from Pulsatilla saponins induced tumor-suppressive M1-like macrophage by activating TLR4/NF-κB/MAPK signaling and subsequently enhanced expression of IL-12 in macrophages to attenuate angiogenesis of breast cancer in vivo and in vitro (Yin et al., 2021).