The combination of asparagus polysaccharide (IC50 ∼ 10 mg/ml) and HIF-1α RNAi significantly inhibited the tube formation in HUVECs under HCC cells (SK-HEP and HEP-3B) induced and tumor angiogenesis in a xenotransplantation mouse model (100 mg/kg by gavage), and reduced the expression of VEGF and HIF-1α by suppressing Akt/Erk axis in vivo and in vitro (Zhu et al., 2021a). This evidence concerns the gene HIF1A and hepatocellular carcinoma.