Curcumin downregulated NF-κB and FAK/P38 MAPK and reduced the expression of VEGF, MMP-2, MMP-9, and COX-2 to exert the anti-tumor angiogenesis attribute in vivo and in vitro (Kumar et al., 2016; Hosseini et al., 2019). This evidence concerns the gene PTGS2 and neoplasm.