KDR and neoplasm: C-type lectin family 14, member A (CLEC14A), overexpressed in tumor endothelial cells, promoted sprouting angiogenesis via VEGF/VEGFR-2/VEGFR-3 pathway (Lee et al., 2017a) and vascular development (Mura et al., 2012; Noy et al., 2016) and mediated cell–cell adhesion via its extracellular C-type lectin-like domain (CTLD) (Rho et al., 2011).