Additionally, N1 neutrophils could be associated with the anti-tumor effects of other immune cells by secreting pro-inflammatory cytokines, such as C-C Motif Chemokine Ligand 2 (CCL2) (Nagarsheth et al., 2017), C-C Motif Chemokine Ligand 3 (CCL3) (Chheda et al., 2016), C-X-C Motif Chemokine Ligand 10 (CXCL10) (Chheda et al., 2016), C-X-C Motif Chemokine Ligand 11 (CXCL11) (Chheda et al., 2016), and interleukin-12 (IL12) (Vignali and Kuchroo, 2012). This evidence concerns the gene CCL2 and neoplasm.