MAPT and Alzheimer disease: In recent years, scientists have constructed a variety of transgenic nematodes to screen AD drug candidates and establish the molecular dynamics of proteins and genes (β-sheet breaking property, Aβ expression level, hyperphosphorylation of Tau, and many more) associated with AD (Morales-Zavala et al., 2017; Ahmad, 2018; Sarasija et al., 2018; Zhu et al., 2019).