TGFB1 and Hepatic fibrosis: Transforming growth factor-beta (TGF-β) is a fibrogenic cytokine activated by the HSC activation and binds to their receptors on cell surface and starts the activation of other transcription factors such as Smad2, collagen alpha 1, and myofibroblasts, thereby promoting hepatic fibrosis (Liu et al., 2019).