When TGFBR1 was inhibited, the effects of BBR on trans-endothelial migration of PC cells in vitro and PC lung metastasis in vivo were both significantly reduced, suggesting a critical involvement of TGFBR1 in BBR inhibiting trans-endothelial migration and lung metastasis of PC cells. Here, TGFBR1 is linked to pachyonychia congenita.