Bi et al. (2021) found that oncogene circ_0004136 could promote AML development through regulating miR-570-3p/TSPAN3 axis while exosome-mediated circ_0004136 knockdown restrained AML cell malignant progression. Our recent study also demonstrated that upregulated circ_0058493 in exosomes derived from CML cells was associated with imatinib resistance (Zhong et al., 2021). Besides, Wu et al. (2020) identified a novel mitochondrial genome-derived circRNAs (Mc), mc-COX2. Here, TSPAN3 is linked to acute myeloid leukemia.