AKT1 and hepatocellular carcinoma: In Liu CY’s study, he observed that TET can activate reactive oxygen species and contribute to human hepatocellular carcinoma apoptosis (Liu et al., 2011), similarly, Wan J. demonstrated that Reactive oxygen species (ROS)/Akt signaling mediates the synergistic antitumor efficacy of sorafenib in conjunction with tetrandrine (Wan et al., 2013).