HIF1A and acute kidney injury: Briefly, significantly lower expression of HIF-1α protein was found in fasudil-treated (vs. untreated) rats with CA-AKI (p < 0.0001); and PHD2 protein concentrations were significantly higher in the CA-AKI + Fasudil (vs. CA-AKI) group (p = 0.001) (Figure 9B).