Several other examples of P2XR-implicated pathological conditions include: platelet aggregation (P2X1), hearing loss (P2X2), asthma (P2X3), vascular inflammation (P2X7), and cancer (P2X7) (Kamei et al., 2005; Baroni et al., 2007; Burnstock and Kennedy, 2011; Furlan-Freguia et al., 2011; Mahaut-Smith et al., 2011; North and Jarvis, 2013; Yan et al., 2013; Burnstock and Knight, 2018; Lara et al., 2020; Illes et al., 2021). This evidence concerns the gene P2RX7 and asthma.