The mechanism of renal fibrosis is sophisticated, and many kinds of signal pathways, such as the transforming growth factor-β (TGF-β)/Smad signaling pathway (Yang et al., 2019), Wnt/β-catenin pathway (Miao et al., 2019), and Notch pathway (Yu et al., 2021), are involved in the progression of renal fibrosis. The gene discussed is TGFB1; the disease is renal fibrosis.