Results showed that the YSHS granule down-regulated the expressions of Bmp2, Gsta1, Gsta3, Bst1, and S100a9 (Figure 5A), and up-regulated the expressions of Ttr and Gatm (Figure 5B) in the kidney tissues of ADR-induced FSGS model mice, while there were no significant changes on the expressions of Igf1, Ren, Pck1, Alb, Pah, Ctsv, Dcxr, and Tnnc1. The gene discussed is IGF1; the disease is focal segmental glomerulosclerosis.