HPGDS and fibrosis: GSTA3, which is one of the most important members of the glutathione transferase family and is involved in the detoxification and cellular defense (Hayes et al., 2005), it was reported to attenuate renal interstitial fibrosis in vivo and in vitro by inhibiting the activity of the TGF-β1 signaling pathway (Xiao et al., 2016; Xiao et al., 2019) and inhibited liver fibrosis through the suppression of the MAPK and GSK-3β signaling pathways (Chen et al., 2019), suggesting that GSTA3 is an effective anti-fibrosis target.