The objectives of the present study are as follows: 1) to study the add-on effect of WS on COPD patient’s pulmonary functioning, quality of life, and exercise tolerance; (2) to find its mechanism of action by evaluating its (a) antioxidant or anti-inflammatory potential; (b) correlating it with lung functioning parameters; and (c) in silico identification of potential inhibitors of MPO and IL-6 proteins; and (3) to identify the phytochemicals present in WS root extract and in silico analyzing their inhibitory activity against ACE-2, thus evaluating its antiviral potential. This evidence concerns the gene ACE2 and chronic obstructive pulmonary disease.