What’s more, Kanikarla-Marie P et al. believed that there could be some connection between unresponsive circulating tumor cells (CTCs) and platelet counts in circulation as escape mechanisms for CTCs from immune surveillance could be achieved by being entrapped within platelet aggregates, or by expressing platelet proteins on their surface and masking themselves (Kanikarla-Marie et al., 2018), and Diem S, et al., showed that patients who had higher platelet counts showed poorer response to PD-L1 therapy (Diem et al., 2017). The gene discussed is CD274; the disease is neoplasm.