Among these pathways, many important signal molecules and transcription factors, including NF-κB, c-fos, and c-jun, are involved in the pathogenesis of RA (Gaafar, et al., 2018; Bao, et al., 2019; Kanai, et al., 2020; Zhao et al., 2021; Zhai., et al., 2019). This evidence concerns the gene JUN and rheumatoid arthritis.