Comparing previous 10 years, there were significant decreases in serum levels of PTH, albumin corrected-Ca and alkaline phosphatase (ALP), as well as tumor size over time (all P<0.001), whilst serum P concentration (P<0.001), eGFR (P<0.001) and BMDs at FN(P=0.016) and TH (P=0.033) increased in recent 10 years. The gene discussed is PTH; the disease is neoplasm.