Results of Diabetes Control and Complications Trial (DCCT) indicated that during the first year of intensive insulin therapy subjects gained more weight (5.1 ± 4.6 kg) than participants treated conventionally (2.4 ± 3.7 kg) (76), and over the course of 6.5 years of the same study about 25% of subjects who were treated with intensive insulin therapy gained more weight than group treated in conventional way what resulted in occurrence of obesity (77). This evidence concerns the gene INS and obesity disorder.