IGF1R and breast carcinoma: In one of the earliest and largest (n = 2871) reports applying these criteria in conjunction with IGF1R expression data from human breast cancer patients, Yerushalmi et al. found a significant positive correlation between high IGF1R expression (IHC Allred score ≥ 7) and breast-cancer-specific survival (BCSS) in patients with luminal-B tumors.