Previously, we crossed the aforementioned MMTV-dnIGF1R line with the widely studied MMTV-Wnt1 mammary tumor model, to generate a double transgenic animal, MMTV-Wnt1/dnIGF1R, to investigate the role of IGF1R signaling in a basal-like mouse model of breast carcinogenesis. The gene discussed is IGF1R; the disease is breast cancer.