BRAF and neoplasm: Mao’s report (27) defined several significant risk factors of cervical LNM in PTC patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion by the systematic review, and meta-analysis and showed bilateral tumors were unrelated to LNM in patients with PTC, regardless of the BRAF V600E mutation.