Combined with the molecular sex differences we found, namely the higher circulating ghrelin levels, reduced LEAP-2, and increased ghrelin receptor expression in emotionality-influencing brain areas of females, the sex divergent response to ghrelin signaling in feeding and anxiety-like behavior suggests that the male response to negative energy balance is primed to increase food intake, whereas the female response largely affects anxiety-like behavior besides food intake. Here, GHRL is linked to Anxiety.