The predictive clinical factors for the resumption of insulin therapy to maintain the optimal glucose control in Korean patients with T2D were as follows: 1) total daily insulin dose at baseline, regarding daily insulin doses, we noted that using the receiver-operating characteristic analysis with a total daily insulin dose of >44U was the cutoff value for predicting insulin resumption, 2) postprandial glucose level, and 3) older age. This evidence concerns the gene INS and type 2 diabetes mellitus.