In another study, the expression of MnSOD and catalase were found to be high in the hearts of SIRT3 overexpressing mice (84), while a third study showed that elabela (a novel peptide that has effects via the apelin receptor) may induce the inhibition of OS by SIRT3 through the deacetylation of FOXO3a, thereby preventing myocardial injury in diabetes (85). The gene discussed is SIRT3; the disease is diabetes mellitus.