In DCM, these disorders of glucose and lipid metabolism cause OS, and the overproduction of ROS not only directly induces inflammation, but also damages DNA, lipids, and proteins, and causes AGE production and O-glycosylation, which in turn activates the NF-κB signaling pathway and induces an inflammatory response. This evidence concerns the gene NFKB1 and familial dilated cardiomyopathy.