SHPRH and melanoma: Loss of SHPRH has also been associated with multiple cancers via 1) loss of heterozygosity of the long arm of chromosome 6, where SHPRH resides, 2) accumulation of SHPRH point mutations in melanoma and ovarian cancer-derived cell lines (Sood et al., 2003), and 3) through the protective action of a circular RNA encoding a 146 amino acid fragment of SHPRH in glioblastoma (Begum et al., 2018; Zhang et al., 2018).