Since plasmalogens have been shown to decrease in the plasma of humans with severe COVID-19 (Schwarz et al., 2021; Snider et al., 2021) and SARS-CoV-2 infection leads to a form of sepsis-associated ARDS, we investigated the role of airway infection with SARS-CoV-2 in K18-hACE2 transgenic mice. Here, KRT18 is linked to Sepsis.