When farnesylated prelamin A accumulates, as in restrictive dermopathy (Navarro et al., 2004, Navarro et al., 2005; Verstraeten et al., 2006), or when mutant farnesylated lamin accumulates, as in Hutchinson-Gilford Progeria Syndrome (HGPS) (McClintock et al., 2006), more tubular invaginations are formed compared to cells of healthy individuals. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.