We and others have recently demonstrated that CUL4B regulates the expression of several tumor suppressors, including MYCN, PIK3CA, HER2, SOX4, C-MYC and CDH2 at the posttranscriptional level (Mi et al., 2017; Qi et al., 2018; Qi et al., 2019; Zhao et al., 2019; Li et al., 2020; Liu et al., 2020). This evidence concerns the gene PIK3CA and neoplasm.