Mutations in human CUL4B cause intellectual disability (Tarpey et al., 2007; Zou et al., 2007), and patients with CUL4B mutations manifest disruptions in skeletal development such as short stature and brachydactyly (Badura-Stronka et al., 2010; Isidor et al., 2010; Kerzendorfer et al., 2011; Ravn et al., 2012). The gene discussed is CUL4B; the disease is Intellectual disability.