IRE1α activation in ER stress of gliomas caused by nutrient starvation or hypoxia leads to VEGF-mediated angiogenesis (Drogat et al., 2007), and IRE1α signaling activation was correlated with the increase of invasion markers expression and tumor infiltration by immune cells (Lhomond et al., 2018). This evidence concerns the gene ERN1 and glioma.