Other examples of PDZ-containing proteins that are essential for brain tumor biology include the Tax-interacting protein (TIP)-1 related to GBM motility (Wang et al., 2014), membrane-associated guanylate kinase inverted 3 (MAGI3), and Protein interacting with C kinase 1 (PICK1), which are inversely correlated with glioma malignancy and progression (Cockbill et al., 2015; Ma et al., 2015). This evidence concerns the gene PICK1 and central nervous system cancer.