In addition, FGF2 can promote proliferation and cell survival through the activation of the Akt signaling pathway (Wang et al., 2015), which corroborates the fact that anti-FGF2 antibodies inhibited both anchorage-dependent and independent tumor growth of glioma U87MG and T98G cells (Takahashi et al., 1992). Here, AKT1 is linked to glioma.