In gliomas, annexin A2 is overexpressed and associated with a mesenchymal and invasive phenotype due to its interaction with transcription factors involved in the epithelial-mesenchymal transition (EMT), such as RUNX1, FOSL2, and BHLHB2 (Kling et al., 2016; Maule et al., 2016). The gene discussed is ANXA2; the disease is central nervous system cancer.