In addition, proteins of the Frizzled family, such as FZD4 and FZD5, participate in the WNT signaling pathway and inflammatory processes in nervous tissue (Zhao et al., 2015) and are related to tumor initiation and cell proliferation of glioma cells (Sarkar et al., 2020), respectively, and can modulate tumor progression. This evidence concerns the gene FZD4 and neoplasm.