Interestingly, not only can IL-1β promote hypoxia-induced apoptosis in GBM through the inhibition of the HIF-1/AM axis (Sun et al., 2014), but it also induces tumorigenicity and promotes the formation of glioma spheres in LN-229 glioma cells (Wang et al., 2012). The gene discussed is IL1B; the disease is glioma.