IRE1α was related to glioma growth, angiogenesis, and invasion (Drogat et al., 2007; Dejeans et al., 2012; Auf et al., 2013; Pluquet et al., 2013; Jabouille et al., 2015; Minchenko et al., 2020). The gene discussed is ERN1; the disease is central nervous system cancer.