Also, many of these novel putative core cartilage GRN genes have been found to be expressed in OA cartilage, and even to have a role during the progression of this skeletal disease, further supporting the importance of these genes during cartilage development (Mentlein 2007; Johnson et al., 2015; Sun et al., 2018; Zhang et al., 2018; Bhattaram and Jones 2019; Rice et al., 2019; Chakraborty et al., 2020; Hasegawa et al., 2020; Shi et al., 2022). Here, GRN is linked to bone disorder.