For example, cisplatin triggers the expression of multiple cytokines including IL-6, CCL2, CCL5, CXCL8, BFGF, G-CSF, and VEGF in cancer cells or stromal cells of TME (Johnson-Holiday et al., 2011; Yan et al., 2014; Zhou et al., 2016). This evidence concerns the gene CCL2 and cancer.